Monocyte-related cytokines in acute myocardial infarction

Hideki Tashiro, Hiroaki Shimokawa, Kunihiko Yamamoto, Mitunori Nagano, Michiko Momohara, Ko hei Muramatu, Akira Takeshita

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

To elucidate the role of monocytes in the cytokine system in acute myocardial infarction (AMI), we examined the time courses of plasma concentrations and generation capacities of monocyte-related cytokines in 17 consecutive patients with uncomplicated AMI (from day 1 to 28) and in 10 control subjects. The concentrations of monocyte-related cytokines were measured by enzyme immunoassay with horseradish peroxidase. Cytokine generation capacity was evaluated by cytokine concentrations in the culture solution 24 hours after incubation of 0.5 ml whole blood with 5 μg lipopolysaccharide. Two distinct patterns of increases in the cytokine concentrations were noted: transient (plasma interleukin [IL]-6) and sustained (plasma macrophage colony-stimulating factor and generation capacities of IL-1α, IL-6, granulocyte colony-stimulating factor, and tumor necrosis factor α). There was no significant increase in the concentrations of other cytokines. These results indicate that the concentrations of the monocyte-related cytokines dynamically change during the course of AMI, suggesting that they may contribute to the inflammatory and subsequent proliferative responses in AMI.

Original languageEnglish
Pages (from-to)446-452
Number of pages7
JournalAmerican Heart Journal
Volume130
Issue number3 PART 1
DOIs
Publication statusPublished - 1995 Sep
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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