Monoclonal antibody B72.3 reactivity with human endometrium: A study of normal and malignant tissues

A. Thor, M. J. Viglione, R. Muraro, N. Ohuchi, J. Schlom, F. Gorstein

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Monoclonal antibody (MAb) B72.3, reactive with a high molecular weight mucin-like glycoprotein [termed tumor-associated glycoprotein (TAG)-72], has been shown previously to react preferentially with adenocarcinomas of the ovary, breast, and colon versus a variety of normal human tissues using immunohistochemical and radioimmunoassay (RIA) techniques. We report here B72.3 reactivity with normal postovulatory endomctria, in contrast to proliferative phase epithelia that were nonreactive. Both immunohistochemical and RIA techniques were used to evaluate this phenomenon. TAG-72 expression was also detected in 100 of endometrial adenocarcinomas (n = 32) examined. No MAb B72.3 reactivity was noted in resting, postmenopausal endometria; however, it was present in hyperplastic lesions and appeared to correlate with the severity of histologic abnormality. The utility of MAb B72.3 for screening, radiolocalization, or perhaps therapy of endometrial adenocarcinoma is also discussed.

Original languageEnglish
Pages (from-to)235-247
Number of pages13
JournalInternational Journal of Gynecological Pathology
Volume6
Issue number3
DOIs
Publication statusPublished - 1987 Sep

Keywords

  • Endometrium
  • Monoclonal antibody b72.3

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology

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