Monitoring adsorption in situ and kinetic studies of low-density lipoprotein onto cholesterol modified dextran using quartz crystal microbalance

Song Yan Han, Dong Bo Liu, Liang Huang, Shen Qi Wang, Qing Ping Liu, Junichi Anzai, Osa Tetsuo, Qiang Chen

Research output: Contribution to journalArticle

Abstract

The use of quartz crystal microbalance (QCM) for monitoring in situ the adsorption of low-density lipoprotein (LDL) onto cholesterol modified dextran (CMD) was described. The kinetic studies were made. The experimental results show that kinetic curves are fitted for that of Langmuir adsorption equation quite well, when LDL mass concentration (ng/μL) are 9.9, 12.38, 14.14, respectively, and the rate constants for adsorption (mol·L-1·s-1) and adsorption capacity (ng/cm2) are estimated to be 0.0477, 0.0536, 0.0628 and 107.6, 139.6, 167.9, respectively. The maximal LDL adsorption capacity attains 284.8 ng/cm2 and the adsorptive efficiency was calculated as 72.91%.

Original languageEnglish
Pages (from-to)1166-1169
Number of pages4
JournalGaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities
Volume26
Issue number6
Publication statusPublished - 2005 Jun 1

Keywords

  • Adsorption
  • Cholesterol modified dextran
  • Low-density lipoprotein
  • Quartz crystal microbalance

ASJC Scopus subject areas

  • Chemistry(all)

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