Molecular Targets of Pyrethroid Insecticides

David B. Sattelle, Daisuke Yamamoto

    Research output: Contribution to journalArticlepeer-review

    83 Citations (Scopus)


    This chapter discusses the candidate molecular targets of pyrethroids and the chemistry and insecticidal actions of these compounds. The vast majority of pyrethroids are esters of carboxylic acids. Fast-acting pyrethroids are designated good knockdown agents. Knockdown by a pyrethroid is the characteristic immobilization of the insect, and although it often precedes a lethal action, this is not always the case. Knockdown may result from actions on the central nervous system of insects. Based on the symptoms of pyrethroid action on whole insects, two distinct classes of pyrethroids (Type I and Type II) have been postulated. Type I compounds include pyrethrins, S-bioallethrin (1R, cis) resmethrin, kadethrin, the 1R, (1) trans and 1R, (1) cis isomers of tetramethrin, phenothrin and permethrin, and an oxime O-phenoxybenzyl ether. Narahashi (1980) proposed the following terminology: Type I for the pyrethroids that induce repetitive firing and Type II for those pyrethroids that depolarize the resting membrane.

    Original languageEnglish
    Pages (from-to)147-213
    Number of pages67
    JournalAdvances in Insect Physiology
    Issue numberC
    Publication statusPublished - 1988 Jan 1

    ASJC Scopus subject areas

    • Insect Science

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