Molecular structures of two tetrodotoxin analogs containing a monooxa-hydrocarbon cage: A computational study

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Using quantum chemical calculations we investigate the molecular structures of two tetrodotoxin (TTX) analogs recently isolated from the Japanese toxic newt Cynops ensicauda popei. These novel analogs are characterized by a monooxa-hydrocarbon cage with a direct C5-C10 bond that replaces one of the ether bridges in the canonical dioxa-adamantane cage of TTX. The computed change in the 13C NMR chemical shifts is in good agreement with the change in the corresponding experimental values that results from the above chemical modification. This confirms the chemical structure assigned to the TTX analogs. A topological analysis of the theoretical electronic charge density indicates that the removal of the oxygen bridge in TTX increases the magnitude of the charge density at the cage critical point. A database search indicates that the monooxa-hydrocarbon cage is also present in other natural products such as cinnzeylanine and platensimycin whose molecular structures have been characterized by single-crystal X-ray diffraction analyses.

Original languageEnglish
Pages (from-to)407-415
Number of pages9
JournalJournal of Molecular Structure
Volume1106
DOIs
Publication statusPublished - 2016 Feb 15

Keywords

  • CSD
  • DFT
  • NMR spectroscopy
  • QTAIM
  • Tetrodotoxin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'Molecular structures of two tetrodotoxin analogs containing a monooxa-hydrocarbon cage: A computational study'. Together they form a unique fingerprint.

Cite this