Molecular structure of extraordinarily stable RNA: model building and X-ray analysis.

S. Fujii, Y. Tanaka, K. Tomita, T. Sakata, H. Hiroaki, T. Tanaka, S. Uesugi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A tridecaribonucleotide, rUGAGCUUCGGCUC which adopts the extraordinarily thermally stable hairpin structure, was chemically synthesized. The crystallographic study of this RNA molecule was done. Crystals grew as plates belonging to space group C2 with a = 38.49A b = 32.30A c = 38.76A and beta = 117.56. and one molecule per asymmetric unit. Intensity data were collected at a resolution 2.1A. Structure determination using molecular replacement method has been underway. The favorable three-dimensional model of hairpin was built by molecular dynamics and molecular mechanics calculations.

Original languageEnglish
Pages (from-to)181-182
Number of pages2
JournalNucleic acids symposium series
Issue number25
Publication statusPublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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