Molecular PET Imaging of Acetylcholine Esterase, Histamine H1 Receptor and Amyloid Deposits in Alzheimer Disease

Nobuyuki Okamura, Kazuhiko Yanai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Depositions of amyloid plaques, neurofibrillary tangles and subsequent neurotransmitter deficits are neuropathological characteristics of Alzheimer's disease. Non-invasive monitoring of these changes in the brain is potentially useful for early diagnosis of Alzheimer's disease. Here we introduce the method for measuring the density of amyloid plaques and neurotransmitters using 11C-labeled donepezil, doxepin and BF-227. Positron emission tomography (PET) imaging by [11C]donepezil visualized the distribution of acetylcholine esterase in the brain. PET study using [11C]doxepin also demonstrated the distribution of histamine H1 receptor in the brain. Density of acetylcholine esterase and H1 receptor was prominently reduced in the patients with Alzheimer's disease. [11C]BF-227 PET successfully visualized neocortical depositions of amyloid plaques in the brain and clearly differentiated the patients with Alzheimer's disease from healthy individuals. These tracers would be useful for early and accurate diagnosis of dementia and monitoring anti-dementia therapy.

Original languageEnglish
Title of host publication13th International Conference on Biomedical Engineering - ICBME 2008
Pages2181-2183
Number of pages3
DOIs
Publication statusPublished - 2009 Dec 1
Event13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
Duration: 2008 Dec 32008 Dec 6

Publication series

NameIFMBE Proceedings
Volume23
ISSN (Print)1680-0737

Other

Other13th International Conference on Biomedical Engineering, ICBME 2008
CountrySingapore
Period08/12/308/12/6

Keywords

  • Alzheimer's disease
  • acetylcholine
  • amyloid
  • histamine
  • positron emission tomography (PET)

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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  • Cite this

    Okamura, N., & Yanai, K. (2009). Molecular PET Imaging of Acetylcholine Esterase, Histamine H1 Receptor and Amyloid Deposits in Alzheimer Disease. In 13th International Conference on Biomedical Engineering - ICBME 2008 (pp. 2181-2183). (IFMBE Proceedings; Vol. 23). https://doi.org/10.1007/978-3-540-92841-6_545