Molecular Pathology of Pancreatic Cancer: Implications for Molecular Targeting Therapy

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21 Citations (Scopus)

Abstract

Pancreatic cancer develops through ductal dysplastic lesions or pancreatic intraepithelial neoplasia (PanIN). The origin of pancreatic cancer remains controversial. Some of the molecular origins of pancreatic cancer have been described. For example, KRAS, SHH, CDKN2A, TP53, SMAD4, and DUSP6 are crucial molecules in the development and progression of pancreatic cancer. Understanding the mechanisms of carcinogenesis could help researchers find the Achilles' heel of pancreatic cancer. Molecular targeting is a promising strategy for curing this devastating disease.

Original languageEnglish
Pages (from-to)S35-S39
JournalClinical Gastroenterology and Hepatology
Volume7
Issue number11 SUPPL.
DOIs
Publication statusPublished - 2009 Nov 1
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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