[Molecular mechanisms for the improvement of wound healing ability of periodontal ligament in Marfan's syndrome].

Masahiro Saito, Takashi Tsuji

Research output: Contribution to journalReview articlepeer-review

Abstract

Marfan's syndrome (MFS) is a systemic disorder of the connective tissues caused by insufficient fibrillin-1 microfibril formation and can cause cardiac complications, emphysema, ocular lens dislocation and severe periodontal disease. ADAMTSL6β, a microfibril-associated extracellular matrix protein that has been implicated in fibrillin-1 microfibril assembly is able to improve microfibril insufficiency in MFS mice model. These findings suggest a new therapeutic strategy for the treatment of MFS through ADAMTSL6β-mediated fibrillin-1 microfibril assembly. We here review effect on ADAMTSL6β to the improvement of microfibril insufficiency in periodontal tissue as a model.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalClinical calcium
Volume22
Issue number1
Publication statusPublished - 2012 Jan
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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