Molecular heat transfer in lipid bilayers with symmetric and asymmetric tail chains

Takeo Nakano, Gota Kikugawa, Taku Ohara

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Intramolecular energy transfer in polymer molecules plays a dominant role in heat conduction in polymer materials. In soft matter where polymer molecules form an ordered structure, the intramolecular energy transfer works in an anisotropic manner, which results in an anisotropic thermal conductivity. Based on this idea, thermal energy transfer in lipid bilayers, a typical example of soft matter, has been analyzed in the present study. Nonequilibrium molecular dynamics simulations were carried out on single component lipid bilayers with ambient water. In the simulations, dipalmitoyl-phosphatidyl-choline (DPPC), dilauroyl-phosphatidyl-choline (DLPC), and stearoyl-myristoyl-phosphatidyl- choline (SMPC), which have two alkyl chains with 16C atoms for each, 12C atoms for each, and 18 and 14C atoms, respectively, were used as lipid molecules. The thermal energy transfer has been decomposed to inter- and intramolecular energy transfer between individual molecules or molecular sites, and its characteristics were discussed. In the case of heat conduction in the direction across the membranes (cross-plane heat conduction), the highest thermal resistance exists at the center of the lipid bilayer, where lipid alkyl chains face each other. The asymmetric chain length of SMPC reduces this thermal resistance at the interface between lipid monolayers. The cross-plane thermal conductivities of lipid monolayers are 4.8-6.5 times as high as the ones in the direction parallel to the membranes (inplane) for the cases of the tested lipids. The overall cross-plane thermal conductivities of the lipid bilayers are reduced to be approximately half of those of the monolayers, due to the thermal resistance at the interfaces between two monolayers. The lipid bilayer of SMPC with tail chains of asymmetric length exhibits the highest cross-plane thermal conductivity. These results provide detailed information about the transport characteristics of thermal energy in soft matter, which are new materials with design flexibility and biocompatibility. The results lead to their design to realize desired thermophysical properties and functions.

Original languageEnglish
Article number061301
JournalJournal of Heat Transfer
Volume135
Issue number6
DOIs
Publication statusPublished - 2013 Jun 3

Keywords

  • Lipid bilayer
  • Nonequilibrium molecular dynamics
  • Thermal boundary conductance
  • Thermal conductivity
  • Thermal energy transfer

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Materials Science(all)
  • Condensed Matter Physics

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