Abstract
The gene responsible for neurofibromatosis type 1 (NF1) encodes a protein similar to GTPase-activating protein (GAP) for the products of ras protooncogenes. Since NF1 protein possesses GAP-like activity, it is suggested that NF1 protein plays a role in the regulation of ras-mediated signal transduction. Impaired function of NF1 protein could therefore, lead to abnormal growth or differentiation of neural crest-derived cells in NF1 patients. Mutations of NF1 gene are also found in sporadic tumors not associated with NF1, supporting the hypothesis that NF1 gene acts as a tumor suppressor gene.
Original language | English |
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Pages (from-to) | 2457-2461 |
Number of pages | 5 |
Journal | Nippon rinsho. Japanese journal of clinical medicine |
Volume | 51 |
Issue number | 9 |
Publication status | Published - 1993 Sep |
ASJC Scopus subject areas
- Medicine(all)