Molecular genetic control of caspases and JNK-mediated neural cell death

Erina Kuranaga, Masayuki Miura

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)

Abstract

Programmed cell death, or apoptosis, plays crucial roles in both development and tissue homeostasis. Apoptosis is widely observed in the nervous system during development. However, the molecular mechanisms underlying why only certain cells are selected to die and the execution of neural cell death itself are largely unknown. Recent genetic studies in mice and Drosophila revealed crucial roles for JNK (c-jun N-terminal kinase) activation in neural cell death. The JNK-mediated initiation of apoptotic mechanisms appears to be an excellent strategy for the fine-tuning of morphogenesis as well as cell selection in nervous tissue.

Original languageEnglish
Pages (from-to)291-300
Number of pages10
Journalarchives of histology and cytology
Volume65
Issue number4
DOIs
Publication statusPublished - 2002 Oct 1
Externally publishedYes

ASJC Scopus subject areas

  • Histology

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