Molecular electrochemical switching element based on diffusive molecular competition for multipoint electrochemical detection of respiration activity of cell aggregates

Kosuke Ino, Yuta Yamada, Yusuke Kanno, Shunsuke Imai, Hitoshi Shiku, Tomokazu Matsue

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Electrochemical techniques have been widely utilized for evaluation of oxygen consumption of cells. For high throughput cell analysis and imaging, several electrode-array devices have been developed. However, it is difficult to incorporate many sensors into a small area using a simple arrangement. In the present study, we developed a novel molecular electrochemical switching element for the incorporation of many sensors for detection of oxygen consumption of cells. The switching element is based on the competition of molecular consumption at an electrode pair. The switching elements are incorporated into an electrochemical imaging device, so that n2 electrochemical sensors are prepared with only 2n connector pads. The device was then applied to evaluate the respiratory activity of cell aggregates. The detection system is a useful tool for the electrochemical imaging of cell respiratory activity without any damage to samples.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalSensors and Actuators, B: Chemical
Volume234
DOIs
Publication statusPublished - 2016 Oct 29

Keywords

  • Cell analysis
  • Detection of respiration activity
  • Electrochemical analysis
  • Electrode-array device
  • Switching element

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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