Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

Masayoshi Mishina, Toshiyuki Takai, Keiji Imoto, Masaharu Noda, Tomoyuki Takahashi, Shosaku Numa, Christoph Methfessel, Bert Sakmann

Research output: Contribution to journalArticle

717 Citations (Scopus)

Abstract

Distinct classes of acetylcholine receptor channels are formed when Xenopus oocytes are injected with combinations of the bovine α-, β-, γ- and δ- or the α-, β-, γ- and ε-subunit-specific messenger RNAs. The conductance and gating properties of the two classes of channels, in conjunction with the developmental changes in the muscular contents of the mRNAs, suggest that replacement of the γ-subunit by the ε-subunit is responsible for the functional alteration of the receptor during muscle development.

Original languageEnglish
Pages (from-to)406-411
Number of pages6
JournalNature
Volume321
Issue number6068
DOIs
Publication statusPublished - 1986 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Mishina, M., Takai, T., Imoto, K., Noda, M., Takahashi, T., Numa, S., Methfessel, C., & Sakmann, B. (1986). Molecular distinction between fetal and adult forms of muscle acetylcholine receptor. Nature, 321(6068), 406-411. https://doi.org/10.1038/321406a0