Molecular diagnosis of tumor angiogenesis and anti-angiogenic cancer therapy

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

Angiogenesis is regulated by the balance of proangiogenic factors and angiogenesis inhibitors, and the imbalance of these regulators is the cause of pathological angiogenesis, including tumor angiogenesis. Angiogenesis is required for tumor growth and metastasis, and thus constitutes an important target for the control of tumor progression. While the benefit of anti-angiogenic therapy is potentially profound, limitations have also been recognized by the results obtained thus far by clinical trials. Precise understanding of the process of angiogenesis should lead us to new regimens for more efficient anti-angiogenic therapy. This review focuses on our current understanding of the molecular mechanism of tumor angiogenic and the status of the anti-angiogenesis approach for cancer treatment.

Original languageEnglish
Pages (from-to)200-206
Number of pages7
JournalInternational Journal of Clinical Oncology
Volume8
Issue number4
DOIs
Publication statusPublished - 2003 Aug 1

Keywords

  • Angiogenesis
  • Angiopoietin
  • Antiangiogenesis
  • VEGF

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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