Molecular diagnosis and new gene engineering in hematological malignancies

T. Funato, J. Fujiwara, S. Fujimaki, M. Kaku

Research output: Contribution to journalReview articlepeer-review

Abstract

Advancement molecular diagnostics in hematological malignancy has provided us with a broad menu of new assays and techniques. By integrating the data gleaned from these techniques we can formulate a more rational broad-based diagnosis. Hematological malignancies have traditionally been classified by morphological criteria. However, molecular advances have provided new insights in the genetic backbone of chimeric genes. These malignancies have shown chromosome abnormalities of translocation with chimeric genes, and revealed the rearrangement of chimeric genes by PCR analysis and quantitative PCR system. This review summarized the recent technology for detecting chimeric genes along with concepts of laboratory performance.

Original languageEnglish
Pages (from-to)887-891
Number of pages5
JournalRinsho byori. The Japanese journal of clinical pathology
Volume48
Issue number10
Publication statusPublished - 2000 Oct

ASJC Scopus subject areas

  • Medicine(all)

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