Molecular design of synthetic receptors with dynamic, imprinting, and allosteric functions

Seiji Shinkai, Masayuki Takeuchi

Research output: Contribution to journalArticlepeer-review

Abstract

Sugar recognition in an aqueous system has been achieved using a boronic acid-diol interaction. Combination with an intramolecular amino group has enabled us to read out the binding process as a change in the fluorescence intensity. The novel interaction has been extended to dynamic sugar sensing utilizing an allosteric effect, molecular imprinting, and control of molecular assemblies.

Original languageEnglish
Pages (from-to)1250-1259
Number of pages10
JournalBiosensors and Bioelectronics
Volume20
Issue number6
DOIs
Publication statusPublished - 2004 Dec 15
Externally publishedYes

Keywords

  • Allosteric effect
  • Boronic acid
  • Molecular assembly
  • PET sensor
  • Sugar recognition

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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