Molecular delivery into a lipid bilayer with a single shock waves using molecular dynamic simulation

Kenichiro Koshiyama, Tetsuya Kodama, Michael R. Hamblin, Apostolos G. Doukas, Takeru Yano, Shigeo Fujikawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Cell permeabilization by shock waves may have application in gene therapy and anticancer drug delivery. In the present study we performed direct molecular dynamic (MD) simulation of the interaction of a single shock wave with a cell membrane to investigate the mechanism of the cell permeabilization. The shock wave was characterized by an impulse that was expressed with a velocity determined by the change in the momentum. The cell membrane was designed as a dipalmitoylphosphatidylcholine (DPPC) lipid bilayer placed between two layers of water molecules. The MD simulation determined the relationship between water penetration into the bilayer, the order parameter, the fluidity of each lipid molecule, and the intensity of impulse. These structural changes in the bilayer may be an important factor in the use of shock waves to produce transient membrane permeability.

Original languageEnglish
Title of host publication4th International Symposium on Therapeutic Ultrasound
Pages104-106
Number of pages3
DOIs
Publication statusPublished - 2005 Mar 28
Event4th International Symposium on Therapeutic Ultrasound - Kyoto, Japan
Duration: 2004 Sep 182004 Sep 20

Publication series

NameAIP Conference Proceedings
Volume754
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other4th International Symposium on Therapeutic Ultrasound
CountryJapan
CityKyoto
Period04/9/1804/9/20

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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