Abstract
Aplysianin-A, an antibacterial glycoprotein in the albumen gland of the sea hare Aplysia kurodai, inhibited the growth of both Gram-positive and Gram-negative bacteria. Aplysianin-A cDNA clones were isolated from an albumen gland cDNA library. Sequence analysis reveals that aplysianin-A is produced as a precursor protein of 556 amino acid residues with a signal peptide of 19 amino acid residues and contains 6 potential N-glycosylation sites. Aplysianin-A mRNA was expressed tissue-specifically in the albumen gland. Homology search reveals that aplysianin-A has a 50% overall amino acid sequence homology to achacin, an antibacterial glycoprotein of the giant African snail Achatina fulica.
Original language | English |
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Pages (from-to) | 373-376 |
Number of pages | 4 |
Journal | FEBS Letters |
Volume | 377 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1995 Dec 27 |
Externally published | Yes |
Keywords
- Antibacterial glycoprotein
- Defense factor
- Sea hare
- cDNA cloning
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology