Molecular cloning of PP2Cη, a novel member of the protein phosphatase 2C family

Ken Ichiro Komaki, Koji Katsura, Motoko Ohnishi, Ming Guang Li, Masato Sasaki, Makoto Watanabe, Takayasu Kobayashi, Shinri Tamura

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We have cloned a novel member of the mouse protein phosphatase 2C family, PP2Cη. Sequence analysis suggests that PP2Cη, PP2Cζ and NERPP-2C constitute a unique subgroup of the PP2C family. PP2Cη had extremely low activity against α-casein compared with PP2Cα and was localized mainly in cell nuclei, suggesting that PP2Cη dephosphorylates a unique nuclear protein(s) in the cells.

Original languageEnglish
Pages (from-to)130-137
Number of pages8
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1630
Issue number2-3
DOIs
Publication statusPublished - 2003 Nov 30

Keywords

  • Cloning
  • Enzyme activity
  • Expression
  • Motif
  • Protein phosphatase 2C
  • Subcellular localization

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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