Molecular cloning of cDNA for sapecin B, an antibacterial protein of Sarcophaga, and its detection in larval brain

Se Rok Lee, Shoichiro Kurata, Shunji Natori

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

A cDNA clone for sapecin B, an antibacterial protein of Sarcophaga, was isolated. This cDNA encoded a precursor protein of sapecin B consisting of a signal sequence (24 residues), prosegment (30 residues) and mature sapecin B (34 residues). Sapecin B was synthesized almost exclusively in the fat body when the larval body wall was injured, but the brain of naive larvae was also demonstrated to contain a significant amount of sapecin B. These findings suggested that sapecin B is a bifunctional protein.

Original languageEnglish
Pages (from-to)485-487
Number of pages3
JournalFEBS Letters
Volume368
Issue number3
DOIs
Publication statusPublished - 1995 Jul 24

Keywords

  • Antibacterial protein
  • Brain
  • Potassium channel inhibitor
  • Sapecin B
  • cDNA

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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