Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2

Kouji Yokoyama, Hiroyuki Suzuki, Ken ichi Yasumoto, Yasushi Tomita, Shigeki Shibahara

Research output: Contribution to journalArticlepeer-review

106 Citations (Scopus)

Abstract

We have cloned the cDNAs encoding tyrosinase-related protein-2 (TRP-2) from a human melanoma cDNA library. Transient expression of the isolated cDNA in HeLa cells established that TRP-2 is DOPAchrome tautomerase. Human TRP-2/DOPAchrome tautomerase is composed of 519 amino acids with a molecular weight of 59 000 and has about 84% identity with the mouse counterpart.

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalBBA - Gene Structure and Expression
Volume1217
Issue number3
DOIs
Publication statusPublished - 1994 Apr 6

Keywords

  • DOPAchrome tautomerase
  • Melanin
  • TRP-2
  • cDNA

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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