Molecular basis of lung tissue regeneration

Hiroshi Kubo

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)

Abstract

Recent advances have expanded our understanding of lung endogenous stem cells, and this knowledge provides us with new ideas for future regenerative therapy for lung diseases. In studies using animal models for lung regeneration, compensatory lung growth, and lung repair, promising reagents for lung regeneration have been discovered. Stem or progenitor cells are needed for alveolar regeneration, lung growth, and lung repair after injury. Endogenous progenitor cells mainly participate in alveologenesis. However, human lung endogenous progenitor cells have not yet been clearly defined. Recently discovered human alveolar epithelial progenitor cells may give us a new perspective for understanding the pathogenesis of lung diseases. In parallel with such basic research, projects geared toward clinical application are proceeding. Cell therapy using mesenchymal stem cells to treat acute lung injury is one of the promising areas for this research. The creation of bioartificial lungs, which are based on decellularized lungs, is another interesting approach for future clinical applications. Although lungs are the most challenging organ for regenerative medicine, our cumulative knowledge of lung regeneration and of endogenous progenitor cells makes clear the possibilities and limitations of regenerative medicine for lung diseases.

Original languageEnglish
Pages (from-to)231-244
Number of pages14
JournalGeneral thoracic and cardiovascular surgery
Volume59
Issue number4
DOIs
Publication statusPublished - 2011 Apr

Keywords

  • Compensatory lung growth
  • Emphysema model
  • Lung endogenous stem cells
  • Lung injury
  • Regenerative medicine

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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