Module strategy for peptide ribonucleic acid (PRNA)-DNA and PRNA-peptide nucleic acid (PNA)-DNA chimeras: Synthesis and interaction of chimeras with DNA and RNA

Ryohei Uematsu, Masahito Inagaki, Mitsuo Asai, Hiroka Sugai, Yoshiki Maeda, Akira Nagami, Hirofumi Sato, Seiji Sakamoto, Yasuyuki Araki, Masaki Nishijima, Yoshihisa Inoue, Takehiko Wada

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Employing the module strategy based on our recent finding that the recognition behavior of peptide ribonucleic acid (PRNA) with complementary DNA/RNA is effectively controlled by the anti-to-syn orientation switching of pyrimidine nucleobase induced by borate ester formation, we designed and synthesized PRNADNA and PRNAPNADNA chimeras. In these chimeras, both of the PRNA (or PRNAPNA) and DNA domains recognize the complementary DNA/RNA to form a stable complex, and the PRNA domain is simultaneously expected to play the dual role of switching the recognition behavior and inhibiting hydrolysis by exonucleases. The complexation and recognition control behaviors of these chimeras with DNA and RNA have been elucidated.

Original languageEnglish
Pages (from-to)350-352
Number of pages3
JournalChemistry Letters
Volume45
Issue number3
DOIs
Publication statusPublished - 2016

Keywords

  • Module strategy
  • Oligonucleotide therapeutics
  • Peptide ribonucleic acid (PRNA)

ASJC Scopus subject areas

  • Chemistry(all)

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