Modulation of transient type K channel cloned from rat heart

Hitoshi Okada, Kuniaki Ishii, Kazuo Nunoki, Takaaki Abe, Norio Taira

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

We have cloned a transient type K channel from rat heart (RH10) and coexpressed a metabotropic glutamate receptor (mGluR5) to study the functional modulation of RH10 coupled to the phosphatidylinositol (PI) hydrolysis. Stimulation of mGluR5 suppressed peak amplitude of RH10 current and affected voltage dependence of activation and inactivation of the channel.

Original languageEnglish
Pages (from-to)430-436
Number of pages7
JournalBiochemical and biophysical research communications
Volume189
Issue number1
DOIs
Publication statusPublished - 1992 Nov 30

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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