Modulation of transient type K channel cloned from rat heart

Hitoshi Okada; Kuniaki Ishii; Kazuo Nunoki; Takaaki Abe; Norio Taira

doi:10.1016/0006-291X(92)91576-C

Modulation of transient type K channel cloned from rat heart

Hitoshi Okada, Kuniaki Ishii, Kazuo Nunoki, Takaaki Abe, Norio Taira

MEN - Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We have cloned a transient type K channel from rat heart (RH10) and coexpressed a metabotropic glutamate receptor (mGluR5) to study the functional modulation of RH10 coupled to the phosphatidylinositol (PI) hydrolysis. Stimulation of mGluR5 suppressed peak amplitude of RH10 current and affected voltage dependence of activation and inactivation of the channel.

Original language	English
Pages (from-to)	430-436
Number of pages	7
Journal	Biochemical and biophysical research communications
Volume	189
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(92)91576-C
Publication status	Published - 1992 Nov 30

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(92)91576-C

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title = "Modulation of transient type K channel cloned from rat heart",

abstract = "We have cloned a transient type K channel from rat heart (RH10) and coexpressed a metabotropic glutamate receptor (mGluR5) to study the functional modulation of RH10 coupled to the phosphatidylinositol (PI) hydrolysis. Stimulation of mGluR5 suppressed peak amplitude of RH10 current and affected voltage dependence of activation and inactivation of the channel.",

author = "Hitoshi Okada and Kuniaki Ishii and Kazuo Nunoki and Takaaki Abe and Norio Taira",

note = "Funding Information: Acknowledgments: We thank Dr. T. Iijima for helpful discussion and critical reading of this manuscript. We are grateful to Dr. S. Nakanishi for providing the mGluR5 clone. This study was supported by Grants-in-Aid for Scientific Research on Priority Area (No. 03253101 and 03253107). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1992",

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doi = "10.1016/0006-291X(92)91576-C",

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T1 - Modulation of transient type K channel cloned from rat heart

AU - Okada, Hitoshi

AU - Ishii, Kuniaki

AU - Nunoki, Kazuo

AU - Abe, Takaaki

AU - Taira, Norio

N1 - Funding Information: Acknowledgments: We thank Dr. T. Iijima for helpful discussion and critical reading of this manuscript. We are grateful to Dr. S. Nakanishi for providing the mGluR5 clone. This study was supported by Grants-in-Aid for Scientific Research on Priority Area (No. 03253101 and 03253107). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1992/11/30

Y1 - 1992/11/30

N2 - We have cloned a transient type K channel from rat heart (RH10) and coexpressed a metabotropic glutamate receptor (mGluR5) to study the functional modulation of RH10 coupled to the phosphatidylinositol (PI) hydrolysis. Stimulation of mGluR5 suppressed peak amplitude of RH10 current and affected voltage dependence of activation and inactivation of the channel.

AB - We have cloned a transient type K channel from rat heart (RH10) and coexpressed a metabotropic glutamate receptor (mGluR5) to study the functional modulation of RH10 coupled to the phosphatidylinositol (PI) hydrolysis. Stimulation of mGluR5 suppressed peak amplitude of RH10 current and affected voltage dependence of activation and inactivation of the channel.

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U2 - 10.1016/0006-291X(92)91576-C

DO - 10.1016/0006-291X(92)91576-C

M3 - Article

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AN - SCOPUS:0027096820

SN - 0006-291X

VL - 189

SP - 430

EP - 436

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

Modulation of transient type K channel cloned from rat heart

Abstract

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