[Modulation of transcriptional regulation during bone and cartilage development and their disease].

Riko Nishimura, Kenji Hata, Rikako Takashima, Michiko Yoshida, Eriko Nakamura, Junpei Kida, Hiroko Yagi

Research output: Contribution to journalReview articlepeer-review

Abstract

Genetic and biochemical studies have identified transcription factors critical and specific for bone and cartilage development. More recent studies revealed the molecular mechanisms how these transcription factors regulate bone and cartilage development. Especially, we appreciate recent advances in molecular function of the complex assembled by these transcription factors and epigenetic regulation of them. Aging, inflammation, biological stress, and disorder of endocrine system induce several bone and/or cartilage diseases by affecting the transcriptional and epigenetic regulation. In this review, we would like to describe the transcriptional and epigenetic regulation during developmental and pathological stages. In addition, we discuss possible application of these information in regeneration of bone and cartilage.

Original languageEnglish
Pages (from-to)1585-1593
Number of pages9
JournalClinical calcium
Volume23
Issue number11
Publication statusPublished - 2013 Nov

ASJC Scopus subject areas

  • Medicine(all)

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