[Modulation of transcriptional regulation during bone and cartilage development and their disease].

Riko Nishimura; Kenji Hata; Rikako Takashima; Michiko Yoshida; Eriko Nakamura; Junpei Kida; Hiroko Yagi

[Modulation of transcriptional regulation during bone and cartilage development and their disease].

Riko Nishimura, Kenji Hata, Rikako Takashima, Michiko Yoshida, Eriko Nakamura, Junpei Kida, Hiroko Yagi

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Abstract

Genetic and biochemical studies have identified transcription factors critical and specific for bone and cartilage development. More recent studies revealed the molecular mechanisms how these transcription factors regulate bone and cartilage development. Especially, we appreciate recent advances in molecular function of the complex assembled by these transcription factors and epigenetic regulation of them. Aging, inflammation, biological stress, and disorder of endocrine system induce several bone and/or cartilage diseases by affecting the transcriptional and epigenetic regulation. In this review, we would like to describe the transcriptional and epigenetic regulation during developmental and pathological stages. In addition, we discuss possible application of these information in regeneration of bone and cartilage.

Original language	English
Pages (from-to)	1585-1593
Number of pages	9
Journal	Clinical calcium
Volume	23
Issue number	11
Publication status	Published - 2013 Nov

ASJC Scopus subject areas

Medicine(all)

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abstract = "Genetic and biochemical studies have identified transcription factors critical and specific for bone and cartilage development. More recent studies revealed the molecular mechanisms how these transcription factors regulate bone and cartilage development. Especially, we appreciate recent advances in molecular function of the complex assembled by these transcription factors and epigenetic regulation of them. Aging, inflammation, biological stress, and disorder of endocrine system induce several bone and/or cartilage diseases by affecting the transcriptional and epigenetic regulation. In this review, we would like to describe the transcriptional and epigenetic regulation during developmental and pathological stages. In addition, we discuss possible application of these information in regeneration of bone and cartilage.",

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T1 - [Modulation of transcriptional regulation during bone and cartilage development and their disease].

AU - Nishimura, Riko

AU - Hata, Kenji

AU - Takashima, Rikako

AU - Yoshida, Michiko

AU - Nakamura, Eriko

AU - Kida, Junpei

AU - Yagi, Hiroko

PY - 2013/11

Y1 - 2013/11

N2 - Genetic and biochemical studies have identified transcription factors critical and specific for bone and cartilage development. More recent studies revealed the molecular mechanisms how these transcription factors regulate bone and cartilage development. Especially, we appreciate recent advances in molecular function of the complex assembled by these transcription factors and epigenetic regulation of them. Aging, inflammation, biological stress, and disorder of endocrine system induce several bone and/or cartilage diseases by affecting the transcriptional and epigenetic regulation. In this review, we would like to describe the transcriptional and epigenetic regulation during developmental and pathological stages. In addition, we discuss possible application of these information in regeneration of bone and cartilage.

AB - Genetic and biochemical studies have identified transcription factors critical and specific for bone and cartilage development. More recent studies revealed the molecular mechanisms how these transcription factors regulate bone and cartilage development. Especially, we appreciate recent advances in molecular function of the complex assembled by these transcription factors and epigenetic regulation of them. Aging, inflammation, biological stress, and disorder of endocrine system induce several bone and/or cartilage diseases by affecting the transcriptional and epigenetic regulation. In this review, we would like to describe the transcriptional and epigenetic regulation during developmental and pathological stages. In addition, we discuss possible application of these information in regeneration of bone and cartilage.

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JF - Clinical calcium

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