Modulation of the anti-candida activity of apo-lactoferrin by dietary sucrose and tunicamycin in vitro

H. Nikawa, L. P. Samaranayake, T. Hamada

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

The sensitivity to apo-lactoferrin (apo-LF) of two oral isolates each of Candida albicans and C. krusei preincubated in either sucrose- or tunicamycin-supplemented media was investigated. Known apo-LF-sensitive isolates of both C. albicans and C. krusei demonstrated significantly increased resistance to apo-LF when preincubated in sucrose-supplemented media, but such preincubation had no effect on an apo-LF-resistant isolate of C. albicans, irrespective of the sugar concentration in the medium. Surprisingly, an apo-LF-resistant isolate of C. krusei demonstrated increased susceptibility to apo-LF when preincubated in sucrose. Further, when preincubated with tunicamycin, a chemical that interferes with candidal cell-wall formation, the susceptibility to apo-LF of the resistant isolates increased significantly. These results, when extrapolated in vivo, imply that dietary sucrose may diminish the anticandidal potency of salivary lactoferrin. However, the aberrant behaviour of a single isolate of C. krusei under these circumstances is possibly due to the different cell-wall structure of this yeast and needs to be further investigated.

Original languageEnglish
Pages (from-to)581-584
Number of pages4
JournalArchives of Oral Biology
Volume40
Issue number6
DOIs
Publication statusPublished - 1995 Jun

Keywords

  • Candida albicans
  • Candida krusei
  • lactoferrin
  • sucrose
  • tunicamycin

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

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