Modulating the microtubule-tau interactions in biomotility systems by altering the chemical environment

S. Bhattacharyya, K. Kim, H. Nakazawa, M. Umetsu, W. Teizer

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Obstacles in microtubule mediated neuronal transport can trigger dementia. We use bio-motility assays, that simulate the neuron chemistry in axonopathy, to screen chemicals, that retain the microtubule dynamics in healthy neuronal activity. Tau protein inhibits microtubule activity and leads to oligomerization. Iron(iii) untangles, whereas mono-sodium-glutamate destabilizes the microtubule oligomer.

Original languageEnglish
Pages (from-to)1296-1300
Number of pages5
JournalIntegrative Biology (United Kingdom)
Volume8
Issue number12
DOIs
Publication statusPublished - 2016 Dec

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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