Modified non-overt DIC diagnostic criteria predict the early phase of overt-DIC

Hideo Wada, Tsuyoshi Hatada, Kohji Okamoto, Toshimasa Uchiyama, Kazuo Kawasugi, Toshihiko Mayumi, Satoshi Gando, Shigeki Kushimoto, Yoshinobu Seki, Seiji Madoiwa, Takashi Okamura, Cheng Hock Toh

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Diagnostic criteria for non-overt disseminated intravascular coagulation (DIC) have been proposed by the International Society of Thrombosis and Hemostasis, but are not useful for the diagnosis of early phase of overt-DIC (pre-DIC). Therefore, in the current study the non-overt DIC diagnostic criteria were modified using the global coagulation tests, the change rate in the global coagulation tests and molecular hemostatic markers to detect the pre-DIC state and were prospectively evaluated in 613 patients with underlying DIC disease. The frequencies of patients with DIC (DIC positive), late onset DIC, and without DIC (DIC absent) were 29.5%, 7.2%, and 63.3%, respectively. The modified non-overt-DIC criteria can correctly predict 43/44 patients (97.7%) who were DIC absent at admission and became DIC positive, within a week (late onset DIC state). The mortality rate was higher in DIC positive compared with pre-DIC (37.6% vs. 22.7%, P < 0.05) or DIC negative (37.6 vs. 13.7%, P < 0.01). It was also significantly higher in pre-DIC compared with DIC negative (P < 0.05). Thus, these modified non-overt DIC diagnostic criteria might therefore be useful for the diagnosis of early-phase DIC.

Original languageEnglish
Pages (from-to)691-694
Number of pages4
JournalAmerican Journal of Hematology
Volume85
Issue number9
DOIs
Publication statusPublished - 2010 Sep
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Modified non-overt DIC diagnostic criteria predict the early phase of overt-DIC'. Together they form a unique fingerprint.

Cite this