Modification of single sodium channels by the insecticide tetramethrin

Daisuke Yamamoto, Fred N. Quandt, Toshio Narahashi

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

(+)-trans-Tetramethrin, a pyrethroid insecticide, markedly prolongs the open time of single sodium channels recorded by the gigaohm-seal voltage clamp technique in a membrane patch excised from the N1E-115 neuroblastoma cell. Single channel conductance is not altered by tetramethrin. The modification by tetramethrin occurs in an all-or-none manner in a population of sodium channels. The observed tetramethrin-induced modification of single sodium channels is compatible with previous sodium current data from axons.

Original languageEnglish
Pages (from-to)344-349
Number of pages6
JournalBrain research
Volume274
Issue number2
DOIs
Publication statusPublished - 1983 Sep 12
Externally publishedYes

Keywords

  • insecticide tetramethrin
  • neuroblastoma
  • patch clamp
  • pyrethroid
  • sodium channel

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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