Modification of single sodium channels by the insecticide tetramethrin

Daisuke Yamamoto, Fred N. Quandt, Toshio Narahashi

    Research output: Contribution to journalArticlepeer-review

    48 Citations (Scopus)


    (+)-trans-Tetramethrin, a pyrethroid insecticide, markedly prolongs the open time of single sodium channels recorded by the gigaohm-seal voltage clamp technique in a membrane patch excised from the N1E-115 neuroblastoma cell. Single channel conductance is not altered by tetramethrin. The modification by tetramethrin occurs in an all-or-none manner in a population of sodium channels. The observed tetramethrin-induced modification of single sodium channels is compatible with previous sodium current data from axons.

    Original languageEnglish
    Pages (from-to)344-349
    Number of pages6
    JournalBrain research
    Issue number2
    Publication statusPublished - 1983 Sep 12


    • insecticide tetramethrin
    • neuroblastoma
    • patch clamp
    • pyrethroid
    • sodium channel

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

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