Modification of carboxyl-terminal region is the cause of activation of the src gene in avian sarcoma virus s2

Shuntaro Ikawa, Tadashi Yamamoto, Kumao Toyoshima

Research output: Contribution to journalArticlepeer-review

Abstract

Viral oncogene product of avian sarcoma virus S2 was reported to have two altera-tions from proto-src product; a substitution of its extreme carboxyl terminus with a peptide of helper viral protein and a point mutation which altered the 501st amino acid from arginine to lysine. However, the following data suggest that lysine501 is more common in proto-src product than arginine501. Proto-src from two independent embryos which we analyzed encoded lysine for the 501st amino acid. Rous sarcoma virus and S1, another isolate which had transduced proto-src, also coded for lysine at the same position. Thus, in the case of S2, the onco-genic activation of the src gene appeared to be achieved with only an alteration at its car-boxyl terminus and enhanced expression by long terminal repeats.

Original languageEnglish
Pages (from-to)611-614
Number of pages4
JournalJapanese Journal of Cancer Research GANN
Volume77
Issue number7
Publication statusPublished - 1986 Jan 1
Externally publishedYes

Keywords

  • Oncogene
  • Retrovirus
  • src

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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