Viral oncogene product of avian sarcoma virus S2 was reported to have two altera-tions from proto-src product; a substitution of its extreme carboxyl terminus with a peptide of helper viral protein and a point mutation which altered the 501st amino acid from arginine to lysine. However, the following data suggest that lysine501 is more common in proto-src product than arginine501. Proto-src from two independent embryos which we analyzed encoded lysine for the 501st amino acid. Rous sarcoma virus and S1, another isolate which had transduced proto-src, also coded for lysine at the same position. Thus, in the case of S2, the onco-genic activation of the src gene appeared to be achieved with only an alteration at its car-boxyl terminus and enhanced expression by long terminal repeats.
|Number of pages||4|
|Journal||Japanese Journal of Cancer Research GANN|
|Publication status||Published - 1986 Jan 1|
ASJC Scopus subject areas
- Cancer Research