Modification of a glassy carbon electrode with diols for the suppression of electrode fouling in biological fluids

Bei Guo, Jun Ichi Anzai, Tetsuo Osa

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21 Citations (Scopus)

Abstract

The surface of a glassy carbon (GC) electrode was modified covalently with ethyleneglycol, diethyleneglycol, 1,2-propanediol, and 1,3-propanediol by electrochemical oxidation in order to suppress the electrode fouling originating from non-specific adsorption of serum proteins. Human serum albumin (HSA) was adsorbed significantly on the surface of a bare GC electrode, which was monitored by cyclic voltammetry in the presence of Fe(CN)4-6/Fe(CN)3-6 ions. In contrast, the diol-modified GC electrodes were scarcely fouled in HSA solution and even in human serum. The results were explained reasonably based on the hydrophilic nature of the diol-modified GC surface.

Original languageEnglish
Pages (from-to)860-862
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume44
Issue number4
DOIs
Publication statusPublished - 1996 Apr

Keywords

  • Anodic oxidation
  • Chemical modification
  • Diols
  • Glassy carbon electrode
  • Protein adsorption
  • Serum albumin

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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