Modeling of the suprachiasmatic nucleus based on reduced molecular clock mechanisms

M. Nakao, Y. Nishimura, K. Aoki, N. Katayama

Research output: Contribution to journalConference article

5 Citations (Scopus)

Abstract

One of the physiological substrates of circadian rhythms is known to be located in the suprachiasmatic nucleus (SCN), which unilaterally contains up to 10,000 or more pacemaker cells. Specific molecular clock mechanisms are working within each cell. Here, in order to prevent complexity explosion in understanding the dynamics of SCN, the molecular clock mechanisms are modeled in a reduced form preserving their dynamical characteristics. The reduced cellular models are coupled by diffusions of activating and suppressing agents so as to construct the whole SCN model. The resulting spatial patterns of entrainment are studied under varied diffusion constants. The simulation results suggest validity of reduction of the molecular dynamics as well as usefulness of the strategy employed to model the hierarchical biological system.

Original languageEnglish
Pages (from-to)2897-2900
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume26 IV
Publication statusPublished - 2004 Dec 1
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: 2004 Sep 12004 Sep 5

Keywords

  • Clock gene
  • Phase response curve
  • Reaction-diffusion

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Fingerprint Dive into the research topics of 'Modeling of the suprachiasmatic nucleus based on reduced molecular clock mechanisms'. Together they form a unique fingerprint.

  • Cite this