Modeling of segmentation clock mechanism in presomitic mesoderm

A. Kazama, Akihiro Karashima, N. Katayama, M. Nakao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Somite is sequentially generated in a head-to-tail order by segmentation of the mesenchymal tissue called presomitic mesoderm (PSM). The segmentation occurs periodically at the anterior end of the PSM, and this periodic segmentation has been suggested to be regulated by a molecular clock. In mouse PSM, the segmentation-related genes change their expression every 120 minutes, and this cyclic expression is essential for regular somite segmentation. In this study, a molecular mechanism of segmentation clock involving Wnt and Delta-Notch signaling pathways is modeled, and reality of the model structure is investigated through simulating biological findings. One dimensional array of the cellular clock models is constructed to simulate spatio-temporal dynamics of the gene-expressions in the PSM. The simulation result suggests that the Wnt gradient across the PSM is involved in the dynamics under concern.

Original languageEnglish
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC 2009
PublisherIEEE Computer Society
Pages3267-3270
Number of pages4
ISBN (Print)9781424432967
DOIs
Publication statusPublished - 2009 Jan 1
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: 2009 Sep 22009 Sep 6

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period09/9/209/9/6

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

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