Modeling of hemodynamics arising from malaria infection

Yohsuke Imai, Hitoshi Kondo, Takuji Ishikawa, Chwee Teck Lim, Takami Yamaguchi

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

We propose a numerical model of hemodynamics arising from malaria infection. This model is based on a particle method, where all the components of blood are represented by the finite number of particles. A two-dimensional spring network of membrane particles is employed for expressing the deformation of malaria infected red blood cells (IRBCs). Malaria parasite within the IRBC is modeled as a rigid object. This model is applied to the stretching of IRBCs by optical tweezers, the deformation of IRBCs in shear flow, and the occlusion of narrow channels by IRBCs. We also investigate the effects of IRBCs on the rheological property of blood in micro-channels. Our results indicate that apparent viscosity is drastically increased for the period from the ring stage and the trophozoite stage, whereas it is not altered in the early stage of infection.

Original languageEnglish
Pages (from-to)1386-1393
Number of pages8
JournalJournal of Biomechanics
Volume43
Issue number7
DOIs
Publication statusPublished - 2010 May 1

Keywords

  • Blood flow
  • Computational fluid dynamics
  • Particle method
  • Plasmodium falciparum
  • Red blood cell

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Biophysics
  • Biomedical Engineering

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