Mode of action of Van-M-02, a novel glycopeptide inhibitor of peptidoglycan synthesis, in vancomycin-resistant bacteria

Kenji Miura, Hidenori Yamashiro, Kouichi Uotani, Satoshi Kojima, Takashi Yutsudo, Jun Lu, Osamu Yoshida, Yoshinori Yamano, Hideki Maki, Hirokazu Arimoto

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Van-M-02, a novel glycopeptide, was revealed to exert potent activities against Gram-positive bacteria, including vancomycin-resistant enterococci (VRE) and vancomycin-resistant Staphylococcus aureus (VRSA). A crude assay system was then used to study the mode of action of Van-M-02 as a peptidoglycan synthesis model of both vancomycin-susceptible and -resistant strains. The results suggested that Van-M-02 inhibits the synthesis of lipid intermediates irrespective of their termini. This inhibitory activity may contribute to the anti-VRE and anti-VRSA activities observed.

Original languageEnglish
Pages (from-to)960-962
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume54
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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