Abstract
Van-M-02, a novel glycopeptide, was revealed to exert potent activities against Gram-positive bacteria, including vancomycin-resistant enterococci (VRE) and vancomycin-resistant Staphylococcus aureus (VRSA). A crude assay system was then used to study the mode of action of Van-M-02 as a peptidoglycan synthesis model of both vancomycin-susceptible and -resistant strains. The results suggested that Van-M-02 inhibits the synthesis of lipid intermediates irrespective of their termini. This inhibitory activity may contribute to the anti-VRE and anti-VRSA activities observed.
| Original language | English |
|---|---|
| Pages (from-to) | 960-962 |
| Number of pages | 3 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 54 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2010 Feb 1 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
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Miura, K., Yamashiro, H., Uotani, K., Kojima, S., Yutsudo, T., Lu, J., Yoshida, O., Yamano, Y., Maki, H., & Arimoto, H. (2010). Mode of action of Van-M-02, a novel glycopeptide inhibitor of peptidoglycan synthesis, in vancomycin-resistant bacteria. Antimicrobial agents and chemotherapy, 54(2), 960-962. https://doi.org/10.1128/AAC.00927-09