TY - JOUR
T1 - Mode of action of Van-M-02, a novel glycopeptide inhibitor of peptidoglycan synthesis, in vancomycin-resistant bacteria
AU - Miura, Kenji
AU - Yamashiro, Hidenori
AU - Uotani, Kouichi
AU - Kojima, Satoshi
AU - Yutsudo, Takashi
AU - Lu, Jun
AU - Yoshida, Osamu
AU - Yamano, Yoshinori
AU - Maki, Hideki
AU - Arimoto, Hirokazu
PY - 2010/2
Y1 - 2010/2
N2 - Van-M-02, a novel glycopeptide, was revealed to exert potent activities against Gram-positive bacteria, including vancomycin-resistant enterococci (VRE) and vancomycin-resistant Staphylococcus aureus (VRSA). A crude assay system was then used to study the mode of action of Van-M-02 as a peptidoglycan synthesis model of both vancomycin-susceptible and -resistant strains. The results suggested that Van-M-02 inhibits the synthesis of lipid intermediates irrespective of their termini. This inhibitory activity may contribute to the anti-VRE and anti-VRSA activities observed.
AB - Van-M-02, a novel glycopeptide, was revealed to exert potent activities against Gram-positive bacteria, including vancomycin-resistant enterococci (VRE) and vancomycin-resistant Staphylococcus aureus (VRSA). A crude assay system was then used to study the mode of action of Van-M-02 as a peptidoglycan synthesis model of both vancomycin-susceptible and -resistant strains. The results suggested that Van-M-02 inhibits the synthesis of lipid intermediates irrespective of their termini. This inhibitory activity may contribute to the anti-VRE and anti-VRSA activities observed.
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UR - http://www.scopus.com/inward/citedby.url?scp=75749108294&partnerID=8YFLogxK
U2 - 10.1128/AAC.00927-09
DO - 10.1128/AAC.00927-09
M3 - Article
C2 - 19933802
AN - SCOPUS:75749108294
VL - 54
SP - 960
EP - 962
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 2
ER -
