Mobilized muse cells after acute myocardial infarction predict cardiac function and remodeling in the chronic phase

Toshiki Tanaka, Kazuhiko Nishigaki, Shingo Minatoguchi, Takahide Nawa, Yoshihisa Yamada, Hiromitsu Kanamori, Atsushi Mikami, Hiroaki Ushikoshi, Masanori Kawasaki, Mari Dezawa, Shinya Minatoguchi

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Background: Multilineage differentiating stress-enduring (Muse) cells are SSEA3 + and CD105 + double-positive pluripotent-like stem cells. We aimed to examine the mobilization of Muse cells into peripheral blood after acute myocardial infarction (AMI) and their effects on left ventricular (LV) function and remodeling. Methods and Results: In 79 patients with AMI, 44 patients with coronary artery disease (CAD), and 64 normal subjects (Control), we measured the number of Muse cells in the peripheral blood by fluorescence-activated cell sorting. Muse cells were measured on days 0, 1, 7, 14, and 21 after AMI. Plasma sphingosine-1-phosphate (S1P) levels were measured. Cardiac echocardiography was performed in the acute (within 7 days) and chronic (6 months) phases of AMI. Muse cell number on day 1 was significantly higher in the AMI (276±137 cells/100 μL) than in the CAD (167±89 cells/100 μL) and Control (164±125 cells/100 μL) groups. Muse cell number peaked on day 1, and had gradually decreased on day 21. Muse cell number positively correlated with plasma S1P levels. Patients with a higher increase in the number of Muse cells in the peripheral blood but not those with a lower increase in number of Muse cells in the acute phase showed improved LV function and remodeling in the chronic phase. Conclusions: Endogenous Muse cells were mobilized into the peripheral blood after AMI. The number of Muse cells could be a predictor of prognosis in patients with AMI.

Original languageEnglish
Pages (from-to)561-571
Number of pages11
JournalCirculation Journal
Volume82
Issue number2
DOIs
Publication statusPublished - 2018

Keywords

  • Acute myocardial infarction
  • LV function
  • LV remodeling
  • Mobilization
  • Muse cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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