Mixing and pumping functions of the intestine of zebrafish larvae

Jinyou Yang, Yuji Shimogonya, Takuji Ishikawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Due to its transparency, the intestine of zebrafish larvae has been widely used in studies of gastrointestinal diseases and the microbial flora of the gut. However, transport phenomena in the intestine of zebrafish larvae have not been fully clarified. In this study, therefore, transport caused by peristaltic motion in the intestine of zebrafish larvae was investigated by numerical simulation. An anatomically realistic three-dimensional geometric model of the intestine at various times after feeding was constructed based on the experimental data of Field et al. (2009). The flow of digested chyme was analyzed using the governing equations of fluid mechanics, together with peristaltic motion and long-term contraction of the intestinal wall. The results showed that retrograde peristaltic motion was the main contributor to the mixing function. The dispersion caused by peristalsis over 30 min was in the order of 10−12 m2/s, which is greater than the Brownian diffusion of a sphere of 0.4 µm diameter. In contrast, anterograde peristaltic motion contributed mainly to the pumping function. The pressure decrease due to peristalsis was in the order of millipascals, which may reduce the activation and maintenance heat of intestinal muscle. These findings enhance our understanding of the mixing and pumping functions of the intestine of zebrafish larvae.

Original languageEnglish
Pages (from-to)152-158
Number of pages7
JournalJournal of Theoretical Biology
Volume419
DOIs
Publication statusPublished - 2017 Apr 21

Keywords

  • Fluid mechanics
  • Numerical simulation
  • Peristaltic motion
  • Transport phenomena
  • Zebrafish intestine

ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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