Mixed osteoclastic/pleomorphic-type giant cell tumor of the pancreas with ductal adenocarcinoma: Histochemical and immunohistochemical study with review of the literature

Mika Watanabe, Hiroshu Miura, Hiroko Inoue, Miwa Uzuki, Yu Noda, Naotaka Fujita, Tadashi Yamazaki, Takashi Sawai

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)

Abstract

We described a rare form of giant cell tumor of the pancreas composed of mixed osteoelastic/pleomorphictype giant cell tumor with ductal adenocarcinoma. Immunohistochemical study showed positive staining of cytokeratin and epithelial membrane antigen for pleomorphic-type giant cells and ductal adenocarcinoma but negative for osteoclastic-type giant cells. Vimentin stained positive in both types of giant cells but negative in adenocarcinoma. Osteoclastic-type giant cells were strongly positive for CD68 and tartarate-resistant acid phosphatase was present in these cells, suggesting the osteoclast-like character. CD68 was negative for both pleomorphic-type giant cells and ductal adenocarcinoma. From these findings, we consider that this tumor might be a carcinosarcoma-like neoplasm consisting of both an epithelial and a histiocytic-mesenchymal component.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalPancreas
Volume15
Issue number2
DOIs
Publication statusPublished - 1997 Aug

Keywords

  • Ductal adenocarcinoma
  • Immunohistochemistry
  • Osteoclastic-type giant cell tumor of the pancreas
  • Pleomorphic-type giant cell carcinoma
  • Tartarate-resistant acid phosphatase

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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