Mixed Corticomedullary Tumor Accompanied by Unilateral Aldosterone-Producing Adrenocortical Micronodules: A Case Report

Sawa Yoshida, Naru Babaya, Hiroyuki Ito, Yoshihisa Hiromine, Yasunori Taketomo, Fumimaru Niwano, Shuzo Imamura, Yuto Yamazaki, Hironobu Sasano, Yumiko Kawabata, Shinsuke Noso, Hiroshi Ikegami

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Mixed corticomedullary tumors (MCMTs) are rare and comprise medullary and cortical cells in a single adrenal tumor. The mechanisms underlying their development have not been fully elucidated. Here, we report a case of MCMT in a 42-year-old woman. Based on the preoperative clinical findings, the patient was diagnosed as having a pheochromocytoma with subclinical Cushing syndrome. Postoperative pathological diagnosis revealed that the tumor demonstrated morphologically distinct medullary and cortical components, which produced catecholamines and cortisol, respectively. Hybrid tumor cells producing both catecholamines and cortisol were not detected. Adrenocorticotropin (ACTH)-positive tumor cells were identified to be present in the pheochromocytoma. This ectopic production of ACTH can contribute to an autonomous cortisol production in a paracrine manner. In addition, micronodules producing aldosterone were detected in the adrenal tissue adjacent to the tumor. The simultaneous development of these 2 lesions may not be correlated with each other; however, this case confirms the importance of a detailed histopathological examination of the adrenal lesions harboring complicated hormonal abnormalities by providing pivotal and indispensable information on their pathogenesis and the possible interaction of the hormones produced in the adrenal gland.

Original languageEnglish
Article numberbvab140
JournalJournal of the Endocrine Society
Issue number10
Publication statusPublished - 2021 Oct 1


  • adrenal glands
  • aldosterone-producing micronodules
  • composite pheochromocytoma
  • mixed corticomedullary tumor
  • subclinical Cushing syndrome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


Dive into the research topics of 'Mixed Corticomedullary Tumor Accompanied by Unilateral Aldosterone-Producing Adrenocortical Micronodules: A Case Report'. Together they form a unique fingerprint.

Cite this