Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation

Bo Van, Miyuki Nishi, Shinji Komazaki, Atsuhiko Ichimura, Sho Kakizawa, Keita Nakanaga, Junken Aoki, Ki Ho Park, Jianjie Ma, Tomomi Ueyama, Takehiro Ogata, Naoki Maruyama, Hiroshi Takeshima

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Mitsugumin 56 (MG56), also known as the membrane-bound O-acyl-transferase family member hedgehog acyltransferase-like, was identified as a new sarcoplasmic reticulum component in striated muscle. Mg56-knockout mice grew normally for a week after birth, but shortly thereafter exhibited a suckling defect and died under starvation conditions. In the knockout skeletal muscle, regular contractile features were largely preserved, but sarcoplasmic reticulum elements swelled and further developed enormous vacuoles. In parallel, the unfolded protein response was severely activated in the knockout muscle, and presumably disrupted muscle development leading to the suckling failure. Therefore, MG56 seems essential for postnatal skeletal muscle maturation.

Original languageEnglish
Pages (from-to)1095-1104
Number of pages10
JournalFEBS Letters
Volume589
Issue number10
DOIs
Publication statusPublished - 2015 Apr 28

Keywords

  • ER stress
  • Gene knockout
  • MBOAT family
  • Sarcoplasmic reticulum
  • Skeletal muscle
  • Unfolded protein response

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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