Mite avoidance decreased mite-specific IgE levels and ameliorated asthma symptoms in subjects who lived in temporary housing after natural disasters

Chiyako Oshikata, Maiko Watanabe, Masatsugu Ishida, Seiichi Kobayashi, Kazuhiro Hashimoto, Naoki Kobayashi, Akiko Yamazaki, Rumi Konuma, Takashi Shimada, Takeshi Kaneko, Yoichi Kamata, Shinichi Kuriyama, Masaru Yanai, Naomi Tsurikisawa

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We previously reported an increased prevalence of asthma among patients who had lived in temporary housing after the 2011 Great East Japan Earthquake. We investigated the prognosis of asthma in former residents of temporary housing after allergen avoidance. Methods: Asthma was diagnosed in adults ≥ 15 years from 2014 to 2019 who had lived in temporary housing in Ishinomaki City for at least 1 year. The disease prognosis after the intervention of allergen avoidance in cases that were followed for more than 3 years during the 6-year study period was analyzed. We measured the Dermatophagoides farinae-specific immunoglobulin E (IgE) levels in serum, and the amount of Dermatophagoides group 1 (Der 1) antigen on their futons or mattresses. We instructed residents in an allergen avoidance strategy that included 32 tasks, including using microfiber bedding covers. Results: Of the 202 examinees who were followed for at least 3 years during the 6-year study period, 72(35.6%) were asthmatic during at least one examination. Of these 72 asthmatics, 55(76.4%) developed the disease after the earthquake, and more than half of the cases that we diagnosed at the examination were mild intermittent asthma. After the allergen-avoidance intervention, both the Der 1 level on the futons or mattresses of residents who were diagnosed with asthma but who were nonasthmatic at the final screening and their serum Der f-specific IgE levels significantly decreased (P<0.01) at the final examination. Conclusion: Antigen avoidance ameliorated mild asthma that was prevalent among residents of temporary housing after the earthquake.

Original languageEnglish
Pages (from-to)171-179
Number of pages9
JournalAllergologia et Immunopathologia
Volume49
Issue number4
DOIs
Publication statusPublished - 2021

Keywords

  • Aspergillus
  • Dermatophagoides farinae
  • Great East Japan Earthquake in 2011.3.11
  • adult asthma
  • allergen avoidance
  • mite-specific IgE
  • temporary housing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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