Missense mutation in Abcg5 in SHRSP Rats does not accelerate intestinal absorption of plant sterols: comparison with wistar rats

Tadateru Hamada, Yoko Kodama, Hitomi Goto, Takeshi Yoshida, Katsumi Imaizumi, Ikuo Ikeda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Stroke-prone spontaneously hypertensive rats (SHRSP) deposit plant sterols in their bodies and have a mutation in ATP binding cassette transporter G5 (Abcg5). Lymphatic recovery rates of campesterol and sitosterol in SHRSP rats were comparable to those in Wistar rats, a strain that does not deposit plant sterols in the body and has no mutation in Abcg5. Higher absorption of stigmasterol and sitostanol was observed in SHRSP rats than in Wistar rats, but the differences between SHRSP and Wistar rats were quite small, because the absorbed amounts of these two sterols were much lower than those of campesterol and sitosterol. The in situ uptake of 3H-sitosterol and 14C-cholesterol solubilized in the bile salt micelle into intestinal mucosa was comparable between SHRSP and Wistar rats. These observations suggest that a mutation in Abcg5 does not greatly influence intestinal absorption of plant sterols in SHRSP rats, at least in comparison with Wistar rats.

Original languageEnglish
Pages (from-to)361-365
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number2
DOIs
Publication statusPublished - 2009 Apr 30

Keywords

  • ATP-binding cassette transporter G5 (ABCG5)
  • ATP-binding cassette transporter G8 (ABCG8)
  • Intestinal absorption
  • Plant sterols
  • Stroke-prone spontaneously hypertensive rats (SHRSP)

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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