MiRNAs and regulation of cell signaling

Atsuhiko Ichimura, Yoshinao Ruike, Kazuya Terasawa, Gozoh Tsujimoto

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by binding to target mRNAs in a sequence-specific manner. A large number of genes appear to be the target of miRNAs, and an essential role for miRNAs in the regulation of various conserved cell signaling cascades, such as mitogen-activated protein kinase, Notch and Hedgehog, is emerging. Extensive studies have also revealed the spatial and temporal regulation of miRNA expression by various cell signaling cascades. The insights gained in such studies support the idea that miRNAs are involved in the highly complex network of cell signaling pathways. In this minireview, we present an overview of these complex networks by providing examples of recent findings. An essential role for miRNAs in the regulation of various conserved cell signaling cascades is emerging. Extensive studies have revealed the spatio-temporal regulation of miRNA expression by these conserved cascades. The insights gained in these studies support the idea that miRNAs are involved in the highly complex network of cell signaling. In this review, we summarize these complex networks

Original languageEnglish
Pages (from-to)1610-1618
Number of pages9
JournalFEBS Journal
Volume278
Issue number10
DOIs
Publication statusPublished - 2011 May

Keywords

  • cell signaling
  • feedback regulation
  • miRNAs
  • regulatory network
  • signal cascades

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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