MiRaGE: Inference of gene expression regulation via microRNA transfection II

Y. H. Taguchi; Jun Yasuda

doi:10.1007/978-3-642-24553-4_19

MiRaGE: Inference of gene expression regulation via microRNA transfection II

Y. H. Taguchi, Jun Yasuda

Tohoku Medical Megabank Organization (ToMMo)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

How each microRNA regulates gene expression is unknown problem. Especially, which gene is targeted by each microRNA is mainly depicted via computational method, typically without biological/ experimental validations. In this paper, we propose a new computational method, MiRaGE, to detect gene expression regulation via miRNAs by the use of expression profile data and miRNA target prediction. This method is tested to miRNA transfection experiments to tumor cells and succeeded in inference of transfected miRNA as only one miRNA with significant P-values for the first time.

Original language	English
Title of host publication	Bio-Inspired Computing and Applications - 7th International Conference on Intelligent Computing, ICIC 2011, Revised Selected Papers
Pages	129-135
Number of pages	7
DOIs	https://doi.org/10.1007/978-3-642-24553-4_19
Publication status	Published - 2011
Event	7th International Conference on Intelligent Computing, ICIC 2011 - Zhengzhou, China Duration: 2011 Aug 11 → 2011 Aug 14

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	6840 LNBI
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Other

Other	7th International Conference on Intelligent Computing, ICIC 2011
Country	China
City	Zhengzhou
Period	11/8/11 → 11/8/14

Keywords

MicroRNA
computational inference
target genes
tumor

ASJC Scopus subject areas

Theoretical Computer Science
Computer Science(all)

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Taguchi, Y. H., & Yasuda, J. (2011). MiRaGE: Inference of gene expression regulation via microRNA transfection II. In Bio-Inspired Computing and Applications - 7th International Conference on Intelligent Computing, ICIC 2011, Revised Selected Papers (pp. 129-135). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6840 LNBI). https://doi.org/10.1007/978-3-642-24553-4_19

MiRaGE : Inference of gene expression regulation via microRNA transfection II. / Taguchi, Y. H.; Yasuda, Jun.

Bio-Inspired Computing and Applications - 7th International Conference on Intelligent Computing, ICIC 2011, Revised Selected Papers. 2011. p. 129-135 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 6840 LNBI).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Taguchi, YH & Yasuda, J 2011, MiRaGE: Inference of gene expression regulation via microRNA transfection II. in Bio-Inspired Computing and Applications - 7th International Conference on Intelligent Computing, ICIC 2011, Revised Selected Papers. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 6840 LNBI, pp. 129-135, 7th International Conference on Intelligent Computing, ICIC 2011, Zhengzhou, China, 11/8/11. https://doi.org/10.1007/978-3-642-24553-4_19

Taguchi YH, Yasuda J. MiRaGE: Inference of gene expression regulation via microRNA transfection II. In Bio-Inspired Computing and Applications - 7th International Conference on Intelligent Computing, ICIC 2011, Revised Selected Papers. 2011. p. 129-135. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-642-24553-4_19

Taguchi, Y. H. ; Yasuda, Jun. / MiRaGE : Inference of gene expression regulation via microRNA transfection II. Bio-Inspired Computing and Applications - 7th International Conference on Intelligent Computing, ICIC 2011, Revised Selected Papers. 2011. pp. 129-135 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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MiRaGE: Inference of gene expression regulation via microRNA transfection II

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