TY - GEN
T1 - MiRaGE
T2 - 7th International Conference on Intelligent Computing, ICIC 2011
AU - Taguchi, Y. H.
AU - Yasuda, Jun
PY - 2011
Y1 - 2011
N2 - How each microRNA regulates gene expression is unknown problem. Especially, which gene is targeted by each microRNA is mainly depicted via computational method, typically without biological/ experimental validations. In this paper, we propose a new computational method, MiRaGE, to detect gene expression regulation via miRNAs by the use of expression profile data and miRNA target prediction. This method is tested to miRNA transfection experiments to tumor cells and succeeded in inference of transfected miRNA as only one miRNA with significant P-values for the first time.
AB - How each microRNA regulates gene expression is unknown problem. Especially, which gene is targeted by each microRNA is mainly depicted via computational method, typically without biological/ experimental validations. In this paper, we propose a new computational method, MiRaGE, to detect gene expression regulation via miRNAs by the use of expression profile data and miRNA target prediction. This method is tested to miRNA transfection experiments to tumor cells and succeeded in inference of transfected miRNA as only one miRNA with significant P-values for the first time.
KW - MicroRNA
KW - computational inference
KW - target genes
KW - tumor
UR - http://www.scopus.com/inward/record.url?scp=84855712136&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855712136&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-24553-4_19
DO - 10.1007/978-3-642-24553-4_19
M3 - Conference contribution
AN - SCOPUS:84855712136
SN - 9783642245527
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 129
EP - 135
BT - Bio-Inspired Computing and Applications - 7th International Conference on Intelligent Computing, ICIC 2011, Revised Selected Papers
Y2 - 11 August 2011 through 14 August 2011
ER -