Abstract
We elucidated the contribution of Vα14 NKT cells to Th1 response and host resistance against mycobacterial infection. In Vα14 NKT cell-deficient mice, host defense and DTH response to Mycobacterium bovis BCG were not different from wild-type mice after pulmonary infection. There was no significant difference in the lung concentrations of IFN-γ between the two strains of mice. In addition, host defense to systemic infection with M. tuberculosis was similar to that of M. bovis. Our results indicate that Vα14 NKT cells play only a marginal role, if any, in the Th1 response and host resistance to mycobacterial infection.
Original language | English |
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Pages (from-to) | 207-210 |
Number of pages | 4 |
Journal | MICROBIOLOGY and IMMUNOLOGY |
Volume | 46 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2002 Jan 1 |
Externally published | Yes |
Keywords
- Host defense
- Mycobacterial infection
- NKT cells
- Th1 response
ASJC Scopus subject areas
- Microbiology
- Immunology
- Virology