Minimal contribution of Vα14 natural killer T cells to Th1 response and host resistance against mycobacterial infection in mice

Kazuyoshi Kawakami, Yuki Kinjo, Kaori Uezu, Satomi Yara, Kazuya Miyagi, Yoshinobu Koguchi, Toshinori Nakayama, Masaru Taniguchi, Atsushi Saito

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

We elucidated the contribution of Vα14 NKT cells to Th1 response and host resistance against mycobacterial infection. In Vα14 NKT cell-deficient mice, host defense and DTH response to Mycobacterium bovis BCG were not different from wild-type mice after pulmonary infection. There was no significant difference in the lung concentrations of IFN-γ between the two strains of mice. In addition, host defense to systemic infection with M. tuberculosis was similar to that of M. bovis. Our results indicate that Vα14 NKT cells play only a marginal role, if any, in the Th1 response and host resistance to mycobacterial infection.

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalMICROBIOLOGY and IMMUNOLOGY
Volume46
Issue number3
DOIs
Publication statusPublished - 2002 Jan 1

Keywords

  • Host defense
  • Mycobacterial infection
  • NKT cells
  • Th1 response

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

Fingerprint Dive into the research topics of 'Minimal contribution of Vα14 natural killer T cells to Th1 response and host resistance against mycobacterial infection in mice'. Together they form a unique fingerprint.

Cite this