Minimal contribution of Vα14 natural killer T cells to Th1 response and host resistance against mycobacterial infection in mice

Kazuyoshi Kawakami; Yuki Kinjo; Kaori Uezu; Satomi Yara; Kazuya Miyagi; Yoshinobu Koguchi; Toshinori Nakayama; Masaru Taniguchi; Atsushi Saito

doi:10.1111/j.1348-0421.2002.tb02687.x

Minimal contribution of Vα14 natural killer T cells to Th1 response and host resistance against mycobacterial infection in mice

Kazuyoshi Kawakami, Yuki Kinjo, Kaori Uezu, Satomi Yara, Kazuya Miyagi, Yoshinobu Koguchi, Toshinori Nakayama, Masaru Taniguchi, Atsushi Saito

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

We elucidated the contribution of Vα14 NKT cells to Th1 response and host resistance against mycobacterial infection. In Vα14 NKT cell-deficient mice, host defense and DTH response to Mycobacterium bovis BCG were not different from wild-type mice after pulmonary infection. There was no significant difference in the lung concentrations of IFN-γ between the two strains of mice. In addition, host defense to systemic infection with M. tuberculosis was similar to that of M. bovis. Our results indicate that Vα14 NKT cells play only a marginal role, if any, in the Th1 response and host resistance to mycobacterial infection.

Original language	English
Pages (from-to)	207-210
Number of pages	4
Journal	MICROBIOLOGY and IMMUNOLOGY
Volume	46
Issue number	3
DOIs	https://doi.org/10.1111/j.1348-0421.2002.tb02687.x
Publication status	Published - 2002 Jan 1
Externally published	Yes

Keywords

Host defense
Mycobacterial infection
NKT cells
Th1 response

ASJC Scopus subject areas

Microbiology
Immunology
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1348-0421.2002.tb02687.x

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Minimal contribution of Vα14 natural killer T cells to Th1 response and host resistance against mycobacterial infection in mice. / Kawakami, Kazuyoshi; Kinjo, Yuki; Uezu, Kaori; Yara, Satomi; Miyagi, Kazuya; Koguchi, Yoshinobu; Nakayama, Toshinori; Taniguchi, Masaru; Saito, Atsushi.

In: MICROBIOLOGY and IMMUNOLOGY, Vol. 46, No. 3, 01.01.2002, p. 207-210.

Research output: Contribution to journal › Article › peer-review

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abstract = "We elucidated the contribution of Vα14 NKT cells to Th1 response and host resistance against mycobacterial infection. In Vα14 NKT cell-deficient mice, host defense and DTH response to Mycobacterium bovis BCG were not different from wild-type mice after pulmonary infection. There was no significant difference in the lung concentrations of IFN-γ between the two strains of mice. In addition, host defense to systemic infection with M. tuberculosis was similar to that of M. bovis. Our results indicate that Vα14 NKT cells play only a marginal role, if any, in the Th1 response and host resistance to mycobacterial infection.",

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AU - Kawakami, Kazuyoshi

AU - Kinjo, Yuki

AU - Uezu, Kaori

AU - Yara, Satomi

AU - Miyagi, Kazuya

AU - Koguchi, Yoshinobu

AU - Nakayama, Toshinori

AU - Taniguchi, Masaru

AU - Saito, Atsushi

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N2 - We elucidated the contribution of Vα14 NKT cells to Th1 response and host resistance against mycobacterial infection. In Vα14 NKT cell-deficient mice, host defense and DTH response to Mycobacterium bovis BCG were not different from wild-type mice after pulmonary infection. There was no significant difference in the lung concentrations of IFN-γ between the two strains of mice. In addition, host defense to systemic infection with M. tuberculosis was similar to that of M. bovis. Our results indicate that Vα14 NKT cells play only a marginal role, if any, in the Th1 response and host resistance to mycobacterial infection.

AB - We elucidated the contribution of Vα14 NKT cells to Th1 response and host resistance against mycobacterial infection. In Vα14 NKT cell-deficient mice, host defense and DTH response to Mycobacterium bovis BCG were not different from wild-type mice after pulmonary infection. There was no significant difference in the lung concentrations of IFN-γ between the two strains of mice. In addition, host defense to systemic infection with M. tuberculosis was similar to that of M. bovis. Our results indicate that Vα14 NKT cells play only a marginal role, if any, in the Th1 response and host resistance to mycobacterial infection.

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Minimal contribution of Vα14 natural killer T cells to Th1 response and host resistance against mycobacterial infection in mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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