Mineralization, biodegradation, and drug release behavior of gelatin/apatite composite microspheres for bone regeneration

Sander C.G. Leeuwenburgh, Junichiro Jo, Huanan Wang, Masaya Yamamoto, John A. Jansen, Yasuhiko Tabata

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

Gelatin microspheres are well-known for their capacity to release growth factors in a controlled manner, but gelatin microspheres do not calcify in the absence of so-called bioactive substances that induce deposition of calcium phosphate (CaP) bone mineral. This study has investigated if CaP nanocrystals can be incorporated into gelatin microspheres to render these inert microspheres bioactive without compromising the drug releasing properties of gelatin microspheres. Incorporation of CaP nanocrystals into gelatin microspheres resulted into reduced biodegradation and drug release rates, whereas their calcifying capacity increased strongly compared to inert gelatin microspheres. The reduced drug release rate was correlated to the reduced degradation rate as caused by a physical cross-linking effect of CaP nanocrystals dispersed in the gelatin matrix. Consequently, these composite microspheres combine beneficial drug-releasing properties of organic gelatin with the calcifying capacity of a dispersed CaP phase.

Original languageEnglish
Pages (from-to)2653-2659
Number of pages7
JournalBiomacromolecules
Volume11
Issue number10
DOIs
Publication statusPublished - 2010 Oct 11
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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