Mimicking multipass transmembrane proteins: Synthesis, assembly and folding of alternating amphiphilic multiblock molecules in liposomal membranes

Takahiro Muraoka, Tatsuya Shima, Tsutomu Hamada, Masamune Morita, Masahiro Takagi, Kazushi Kinbara

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Alternating amphiphilic multiblock molecules 1–4, involving fluorescent hydrophobic units, were designed as mimics for multipass transmembrane proteins. Fluorescence spectroscopy of 1–4 in liposomal membranes suggested the face-to-face stacking of the hydrophobic units to give folded structures as well as intermolecular assemblies.

Original languageEnglish
Pages (from-to)194-196
Number of pages3
JournalChemical Communications
Volume47
Issue number1
DOIs
Publication statusPublished - 2011 Dec 6

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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