@article{718f06317c1a44de9b46ba7c5bd3027c,
title = "Millifolides a-c. new 1,10-seco-guaianolides from the flowers of Achillea millefolium",
abstract = "Ten 1,10-secoguaianolides were isolated from the flowers of Achillea millefolium. Their structures were determined on the basis of spectroscopic methods. Three of them (millifolides A-C) including two dimeric sesquiterpenoids exhibit new skeletons. Seco-tanapartholide A exhibited moderate cell growth inhibitory activity against the human cancer cell line MCF7WT (IC50 = 5:51μm) in vitro.",
keywords = "1,10-Seco-guaianolides, Achillea millefolium, Cell Growth Inhibition, Millifolides A to C, Structure Elucidation",
author = "Yong Li and Ni, {Zhi Yu} and Zhu, {Meng Chu} and Kai Zhang and Wu, {Yi Bing} and Mei Dong and Shi, {Qing Wen} and Huo, {Chang Hong} and Fran{\c c}oise Sauriol and Hiromasa Kiyota and Gu, {Yu Cheng} and Bin Cong",
note = "Funding Information: The HMBC experiments verified the above fragments. The assembly of the two partial structures A and B is supported by HMBC correlations from H-6 to C-1, C-4 and C-5 and allowed no alternative structure. One interesting feature in the HMBC experiment was that H-3 showed a correlation with C-3. This observation suggested that this compound was a symmetric dimer. This hypothesis was corroborated by the FAB mass spectrum. The molecular formula of 1, C30H34O9, was calculated by high-resolution molec- Funding Information: The authors gratefully acknowledge the financial supports from the National Natural Science Foundation of China (81072551), the Key Projects of Science & Technology of Hebei Province (11276103D-89), the Scientific Research Foundation for the Returned Overseas Chinese Scholars of Hebei Province (2006-02), and the Scientific Research Foundation of Hebei Province (08B032 and C2010000489). We also wish to extend our sincere thanks for the financial support from Syngenta Ltd. (2011-Hebei Medical University-Syngenta-03) and the Japan Society for the Promotion of Science (Nos. 19580120 and 22580112).",
year = "2012",
month = may,
doi = "10.5560/ZNB.2012-0028",
language = "English",
volume = "67",
pages = "438--446",
journal = "Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences",
issn = "0932-0776",
publisher = "Verlag der Zeitschrift fur Naturforschung",
number = "5",
}
