Millifolides a-c. new 1,10-seco-guaianolides from the flowers of Achillea millefolium

Yong Li, Zhi Yu Ni, Meng Chu Zhu, Kai Zhang, Yi Bing Wu, Mei Dong, Qing Wen Shi, Chang Hong Huo, Françoise Sauriol, Hiromasa Kiyota, Yu Cheng Gu, Bin Cong

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)


    Ten 1,10-secoguaianolides were isolated from the flowers of Achillea millefolium. Their structures were determined on the basis of spectroscopic methods. Three of them (millifolides A-C) including two dimeric sesquiterpenoids exhibit new skeletons. Seco-tanapartholide A exhibited moderate cell growth inhibitory activity against the human cancer cell line MCF7WT (IC50 = 5:51μm) in vitro.

    Original languageEnglish
    Pages (from-to)438-446
    Number of pages9
    JournalZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
    Issue number5
    Publication statusPublished - 2012 May


    • 1,10-Seco-guaianolides
    • Achillea millefolium
    • Cell Growth Inhibition
    • Millifolides A to C
    • Structure Elucidation

    ASJC Scopus subject areas

    • Chemistry(all)


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