Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex

Zhenhua Ding, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

191 Citations (Scopus)

Abstract

Direct alkenylation of the C2-position of indoles bearing an easily removable N-pyrimidyl group with alkynes has been achieved by using a cobalt catalyst complexed with a phosphine-pyridine bidentate ligand. This reaction has wide substrate scope and is highly efficient and stereoselective at room temperature. The alkenylated indoles serve as useful platforms for further synthetic transformations (some products of these transformations are shown in the scheme).

Original languageEnglish
Pages (from-to)4698-4701
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number19
DOIs
Publication statusPublished - 2012 May 7
Externally publishedYes

Keywords

  • alkyne
  • C-H activation
  • cobalt
  • hydroarylation
  • indoles

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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